Seizure susceptibility in prenatally methamphetamine-exposed adult female rats

Abstrakt

The purpose of the present study was to examine the effect of prenatal methamphetamine (MA) exposure on seizures induced by bicuculline and N-methyl-d-aspartate in adult female rats. The present results show that prenatal MA exposure alters seizures in a model-specific manner and that the seizure susceptibility of adult female rats may be affected by the stage of their estrous cycle.

Klíčová slova

• methamphetamine
• prenatal drug
• estrous cycle
• seizure
• GABA
• NMDA
• bicuculline