Abstract
Neuroimaging methods could detect the change of cerebral activity subsequent to the repetitive transcranial magnetic stimulation (rTMS). In the simple view the high frequency (HF) rTMS over prefrontal cortex is able increase metabolism under the coil, while low frequency (LF) rTMS over prefrontal cortex is able to decrease the metabolism in this area.
The connection of neuroimaging methods and rTMS offers unique possibility to choose the localisation and frequency of rTMS in individual patient base on neuroimaging assessment. Authors described a patient with pharmacoresistant depression, which did not respond to LF-rTMS over right prefrontal cortex but responded to HF-rTMS over same area.
The PET scan before rTMS showed decreased metabolism in right prefrontal cortex what is in agreement with simplex model of prediction of antidepressive effect of rTMS depending on metabolism before treatment.