Charles Explorer logo
🇬🇧

Developmental instability, genes, brain lateralization and schizophrenia: an open-ended story

Publication |
2005

Abstract

Dermatoglypics mirror developmental integrity of ectoderm and thus CNS as well. Those markers are formed by the end of the second trimester.

Paired symmetry of epidermal ridges establish an important variable - fluctuating asymmetry (FA) which is a marker of developmental instability in the given subject. Buffering mechanisms which subserve allowable extent of developmental instability could be insufficiently consolidated in evolutionary novel traits.

Functional asymmetry of the human brain belongs undoubtedly towards such a phenotypes. As a result, functionally lateralized areas maybe more prone to developmental perturbations due to mutations and environmental insults in susceptible subjects.

The article provides incentives towards further research covering correlations of developmental instability with functional lateralization impairment in schizophrenia.