Abstract
Depressive disorder is relatively common disease in population. Lifetime prevalence of major depression is 5-12% in men and 9-26% in women.
Approximately 30% of patients treated with first antidepressants achieve remission. The resistant depression is commonly defined as depression which was unsuccessfully treated by 2 antidepressants from various groups.
The authors comment possibilities of resistant depression treatment (change of antidepressants, augmentation and combination of antidepressants, repetitive transcranial magnetic stimulation, electroconvulsive therapy etc.).