Increasing risk of bleeding in treatment with serotonin reuptake inhibitors

Abstract

Epidemiological studies in a large cohorts of patients indicate that selektive serotonin reuptake inhibitors may moderately increase th erisk of bleeding.Although the incidence of upper gastrointestinal bleeding after selective serotonin reuptake inhibitors alone may appear relatively low.The risk of GIT bleedeing may increase markedly in combination with non-steroidal anti-inflammatory drugs.Most at risk are elderly nad those with previous ulcers or gastrointestinal bleeding.

Keywords

• SSRIs
• NSAIDs
• bleeding
• serotonin
• platelets
• drug interactions