Publication at Third Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2006
Abstract
Physostigmine was isolated from Calabar (ordeal) beans in 1864 and used for glaucoma therapy. Nowadays its main indication is the treatment of the central anticholinergic syndrome which is a relatively common complication of general anaesthesia and analgesic sedation in the ICU.
The pharmacokinetic and pharmacodynamic properties and interactions of physostigmine with drugs commonly used in anaesthesia (volatile anaesthetics, propofol, benzodiazepines, opioides and dehydrobenzperidole) are described. A short review of the central anticholinergic syndrome symptoms and therapy is presented.
Physostigmine effects on ethyl alcohol intoxication, muscle shivering and Alzheimer?s disease are also mentioned