Abstract
This study evaluates the results of preoperative Power Doppler sonography with 3D reconstruction and other diagnostic methods based on their comparison with postoperative assessment of tumor extension in a radical prostatectomy specimen. One hundred forty-six patients with clinically localized cancer diagnosed per rectum (DRE) and PSA level lower than 20 g/ml were enrolled into the study and subjected to radical prostatectomy.
Each patient underwent transrectal sonography (TRUS), Power Doppler sonography with 3D reconstruction (3D-PDS), and the risk of the occurrence of locally advanced tumor was assessed using Partin tables. In subgroups of localized and locally advanced tumor, individual preoperative parameters (age, prostate volume, PSA, PSA density, Gleason score, risk of locally advanced cancer according to Partin tables, DRE, TRUS, and 3D-PDS) were compared.
ROC curves were generated for individual preoperative parameters and the area under the curve (AUC) was calculated. Multivariate logistic regression analysis was performed to determine independent predictors of extraprostatic tumor extension