Publication at Third Faculty of Medicine |
2007
Abstract
In this study we have shown that pain threshold and body weight in rats with neonatal hippocampal lesion are influenced by seasonal factors in different way. In spring, pain threshold was lower in QUIN treated then in NAAG treated animals whereas in summer there were no differences between groups.
On contrary, differences in the body weight were greater in spring then in summer and the body weight positively correlated with pain threshold in QUIN treated rats and negatively with NAAG treated rats. We conclude that greater seasonal variations in NAAG animals suggest weaker neurotoxic damage, because similar variation was described in control animals