Functional Connectivity in Obsessive-Compulsive disorder: a correlational analysis of low-resolution brain electromagnetic tomography (LORETA)
Abstract
This study compared cortical functional connectivity between patients with obsessive-compulsive disorder (OCD) and healthy controls using voxel-wise electrical activity (current density) correlations estimated by LORETA (low-resolution brain electromagnetic tomography). 16 OCD patients (10 men and 6 women) on stable, benzodiazepine-free medication participated in the study. The mean current density in three a priori selected homologous cortical regions (anterior cingulate, superior temporal cortex and orbitofrontal cortex) was correlated in time with current density in the remaining of 2394 cortical voxels.
The individual z-scores obtained by normative database comparisons were analyzed with randomization-permutation statistics. In OCD patients, anterior cingulate and orbitofrontal cortex showed significantly lower correlations with a large frontotemporal region of the right hemisphere, mainly in the low-frequency band.