NF-kappaB, colorectal carcinoma and radiotherapy: results of a clinical and experimental study

Abstract

he aims of this study were: 1) to assess expression of NF-kappaB in rectal cancer patients and to evaluate its possible predictive and prognostic role; 2) to determine in in vitro experiments the level of NF-kappaB activation before and after radiation, to assess possibilities of NF-kappaB inhibition, and to evaluate, whether this inhibition may improve efficiency of radiation therapy

Keywords

• NF-kappaB
• rectal cancer
• radiotherapy
• immunohistochemistry
• marker