Abstract
Backround: Three small-scale studies have revealed that decrease of frontal theta cordance after 1 week on antidepressant medication can predict clinical response to treatment. It is important for clinical practices to know 1) if EEG cordance predicton is valid to antidepressant therapy in general not only to antidepressants 2) if we can used it in sequening antidepressants prediction too.
Methods: We used categorial variable - decrease of frontal theta cordance predict response to treatment, the absence of cordance decrease predict clinical non-response. Results: First patient with failure of 3 antidepressants therapy decreased frontal cordance after 1 week of rTMS and responded to rTMS monotherapy after 4 weeks of the stimulation.
Second patient with failure of 5 antidepressant trials did not decrease frontal cordance after first week of new treatment (venlafaxine) and after 4 week did not respond to venlafaxine therapy. After lithium augmentation we observed clinical improvement together with front