Intracoronary injection of autologous bone marrow-derived mononuclear cells in patients with large anterior acute myocardial infarction: a prematurely terminated randomized study
2007
Abstrakt
We designed a randomized study to test the safety and efficacy of intracoronary injection of autologous bone marrow-derived mononuclear cells (BMNCs) in patients with large acute anterior myocardial infarction and late presentation, who were treated with successful primary PCI. Eligible patients were randomly assigned in 2:1 ratio either to intracoronary BMNCs injection (n=17) or standard medical therapy (n=10).
This randomized study showed that intracoronary infusion of BMNCs in the infarct-related coronary artery does neither increase recovery of LV ejection fraction, nor reduce LV volumes and infarct size at 4 months, as compared to controls