Is decrease of social interraction induced by low dose methamphethamine caused by anxiogenic effect?
2008
Abstract
Psychostimulants change behavior of an individual. We have proven that methamphetamine (MA) at the dose 1.0 mg/kg decreases time of social interaction in the social interaction test (SIT).
In general this considered to be a demonstration of an anxiogenic effect. To confirm this finding we implemented on the other animals further test of anxiety elevated plus maze (EPM).
Although, we have establish that social interaction decreases proportionally to dosage of MA 0.5, 1.0, 1.5 mg/kg, in the test EPM we did not find any significant differences between those doses. From the results we can conclude that single injection MA at the low dosages affects social interaction, however, this is not caused by anxiogenic effect of the drug.