The Validity of Animal Models of Schizophrenia Based on the Inhibition of NMDA Receptor-Animal and Clinical Studies
2008
Abstract
When evaluating disease models, a notion of validity (phenomenological, predictive and constructive) is used to determine to what extent the model really corresponds to selevted features of the particular disease. This article sums up results of studies that have used the administration of NMDA receptor inhibitors as a model of schizophrenia in animals, healthy human volunteers and schizophrenia patients.
The studies show that, despite certain limitations, both acute and chronic administration of NMDA receptor inhibitors represents a valid model of schizophrenia