Genetic principle of Alzheimer's disease and possibility of its prediction

Abstract

This minireview is focused at recent genetic research allowing new strategies in the prediction of AD in spite of complexity and genetic heterogeneity of this devastating disease with great social and economic impacts.

Keywords

• gamma-secretase
• Alzheimer's disease
• Amyloid peptide
• Amyloid precursor protein
• Apolipoprotein E
• Dementia
• Genetic prediction
• Glutamate receptors
• Presenilin
• Risk genes
• Tau protein