Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess
2009
Abstrakt
The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner.