Abstract
The number of multiple cancers were evaluated among 118 546 women diagnosed with a first primary breast cancer during 1976-2005, of which 10 352 (52.7%) were initial and 9 309 (47.3%) subsequent breast cancers, registered as of 17. 10. 2007. There were 17 085 (14.4%) women with two, 2 138 (1.8%) with three and 438 (0.4%) with four and more primary cancers.
The subsequent 8 509 (43.3%) breast cacers were the 2nd, 673 (3.4%) the 3rd, 87 (0.4%) the 4th and 40 (0.2%) the 5th till the 12th diagnosis. The numbers of 10 352 primary breast cancers increased during 1976-1994 and then decreased, numbers of 9 309 subsequent breast cancers increased till 2004.
Total 10 352 women, diagnosed in 22.1% of stage I, 45.5% of stage II, 17.7% of stage III, 4.2% of stage IV and 10.6% unknown, were followed 11 522 second primary neoplasms of that the most frequent were cancers of breast 27%, skin 19.4%, digestive system 17% and female genital system 15.5%. Total 3 112 bilateral breast cancers accounted 2.6% of 118 546 cases, registered in Czech Cancer Registry.
The average interval between the breast and subsequent cancer were 6 years, the proportion of synchronous and metachronous cancers were 1 : 5.1. The average survival interval of 10 352 women with breast multiplicities were 8.1 year, of which 35.1% women survived and 64.9% died as of 17. 10. 2007.