Publication at Third Faculty of Medicine |
2009
Abstract
In this article new knowledge of the epidemiology of chronic HBV infection is introduced and the importance of HBeAg seroconversion for correct indication of antiviral treatment is assessed. Further the importance of low viraemia at end of treatment as a main goal of antiviral therapy along with a very low ALT activity in the lower half of normal values, which is crucial for the prevention of liver cirrhosis and hepatocellular carcinoma, is stressed.
Quite recent is information on the efficacy and safety of tenofovir disoproxil fumarate when compared with adefovir dipivoxil.