Abstrakt
Topical corticosteroids and local anaesthetics have been used for many years to relieve symptoms of anorectal diseases, such as pain, pruritus and bleeding. Few clinical trials have been published to allow comparisons of different combinations or different formulations, mainly because many of these products came to market before stringent peer review of clinical trials data was a prerequisite for registration.
This article highlights why topical medications are necessary for the treatment of anorectal diseases, especially of inflammatory symptoms of haemorrhoids, anal eczema and others, particularly with respect to improving the quality of life of patients living with the pain and discomfort associated with such symptoms. It also demonstrates the efficacy and safety of combinations of topical corticosteroids and local anaesthetics in cream and suppository through reference to published clinical trials data, previously unpublished clinical trials data and real life clinical experience with these products.