Fibrinolytic inhibitors in cardiac surgery - a view from the end of the first decade of the new millennium
2010
Abstract
Preventive application of fibrinolytic inhibitors in cardiac surgery has been used to reduce perioperative blood loss and transfusion requirements since the 1980s. The article describes the history of introducing aprotinin into practice and deals with the circumstances leading to its recent withdrawal from the pharmaceutical market.
It briefl y summarizes the current view on synthetic lysine analogs both in cardiac surgery and other fields of surgery.