Abstract
Nonpharmacological interventions (physical activity and low-caloric diet) play a key role in obesity and type 2 diabetes management. The beneficial effects of these interventions on metabolic and cardiovascular profiles of the subject are assocciated with the decrease of adipose tissue and changes in adipose tissue metabolism, including lipolysis.
Lipolysis (triglyceride hydrolysis into glycerol and NEFA) is regulated by a number of hormonal sinals, the main being catecholamines, insulin, atrial natriuretic hormone. Importance of particular signalling depends on actual physiological condition of organism.
Physical activity, basic preventive and therapeutic approach in most civilization diseases management, presents significant stimulus of lipolysis. During acute bout of exercise, adipose tissue lipolytic activity increases due to major stimulation of beta-adrenoreceptors and decrease in plasma level of insulin, main antilipolytic hormone.
Basal lipolysis is suppressed or not changed and exercise-induced lipolysis is stimulated by the chronic physical activity, but the literature provides controversial findings.