Expression of GluN1C2 subunit of NMDA receptor in hippocampus of patients suffered with schizophrenia - post mortem study
2010
Abstract
Changed expression of GluN1 subunit of N-methyl-D-aspartate receptor is repeatedly observed in schizophrenia. GluN1 C2 (C2 cassette), variant of this subunit, is important for insertion GluN1 into the plasma membrane.
We have assessed protein expression of GluN1 C2 post mortem in left and right hippocampi of patients with schizophrenia and control. The results showed interaction of laterality and sex and the laterality in man was in reverse to laterality in women.
Relation between expression levels and schizophrenia diagnosis was not proven