Abstract
The efficacy of antihypertensive therapy on cardiovascular mortality and morbidity is based on the effect on blood pressure lowering. Effective decrease of blood pressure is provided by: thiazide diuretics, beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
These drugs represent the treatment of choice either for monotherapy, or for the combination. Pharmacotherapy of hypertension is guided either by blood pressure level, the presence of associated clinical condition, the severity of target organ damage and the total cardiovascular risk.
Up-to now, there is no evidence of the treatment benefit in the management of high normal blood pressure. The choice of the treatment drug group depends on the type of the associated clinical condition