Publication at First Faculty of Medicine, Third Faculty of Medicine |
2011
Abstract
Objective: The elucidate the mechanism of hypotension caused by intravenous administration of paracetamol (acetaminophen) in the critically ill. Mechanically ventilated critically ill patients monitored by PiCCO who were concurrently administered i.v. paracetamol were eligible for the study.
We recorded the haemodynamic indices, the core and peripheral temperatures continuously for 3 hours after the administration of paracetamol or a control drug known not to influence the haemodynamics. Conclusion: Intravenous paracetamol alters the haemodynamics in a subset of critically ill patients by decreasing both the cardiac output and systematic vascular resistance.