Comparision of the effects of two hallucinogens, psilocin and meskaline, in quantitative eeg and in senzorimotor information processing in the animal model of psychosis
2011
Abstract
Deficits in senzorimotor information processing as well as some changes in quantitative EEG (qEEG) are characteristic for schizophrenia.This study focuses on a comparision of two hallucinogens, tryptamine (psilocin) and phenylethylamine (meskaline), in an animal model of psychosis. The registration of qEEG was performed from 12 subdural electrodes placed on six homologous sites of frontal, motor, parietal and temporal cortex in freely moving rats.
Both substances disrupted senzorimotor information processing as well as they both decreased functional connectivity in qEEG (i.e. decrease in power spectra and coherence). Our data are similar to findings of schizophrenia patients, confirming validity of used models