Abstract
The aim of this study was GC-MS screening of drinking water supplies for the presence of traces of pharmaceuticals. The target analytes were naproxen, ibuprofen, diclofenac, carbamazepine and 17?-ethynylestradiol.
Solid-phase extraction (SPE) was used for for their preconcetration. Derivatization of target analytes in the eluted extracts was performed using N-(tert-butyldimethylsilyl)- N-methyltrifluoroacetamide.
Limits of quantification were less than 0.5 ng/L for naproxen, ibuprofen, diclofenac, carbamazepine and less than 2.0 ng/L for 17?-ethynylestradiol. The presence of target pharmaceuticals in drinking water in the Czech Republic is very rare.