Many signs of aging, such as sexual dysfunction, visceral obesity or reduction of bone and muscle strength, may be caused by hypogonadism. Correction of low levels of circulating androgens may improve aging symptoms.
But as yet there is no definitive proof of long term safety of hormone replacement testosterone therapy to male body. By the contrary, there is evidence that testosterone is a main factor in the development of prostate cancer.
The aim of the review article is to summarize adverse events of hormone replacement testosterone therapy in man treated for testosterone deficiency.