The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas
2013
Abstract
This study deals with the monitoring of the plasmatic level of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by HPLC after derivatization employing 2,4-dinitrophenylhydrazine.
A clinical study involving 20 female patients suffering from ovarian and endometrical carcinomas has demonstrated elevated levels of malondialdehyde (10.1 +- 1.1 µM), compared with the control group (7.5 +- 2.7 µM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content.
This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery.