Abstract
Primary central nervous system lymphomas constitute a rare group of extranodal non-Hodgkin's lymphoma with aggressive clinical course and unsatisfactory outcome. High dose methotrexate based chemotherapy combined with whole brain radiotherapy is the current standard of treatment.
Combination of chemotherapy and whole brain radiotherapy improves response rate, however, the addition of radiotherapy increases the risk of neurotoxicity. Radiotherapy alone is a therapeutic approach in older patients not suitable for systemic chemotherapy.
The significance of high dose chemotherapy with autologous stem cell transplantation and new drugs are investigated in the current clinical trials in primary central nervous system lymphomas