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Comorbidity of migraine and depression - a meta-analysis

Publication |
2013

Abstract

The aim of the study: The aim of our study was to support the supposition of an association between migraine and depression. Methods: We reviewed 20 population-based crosssectional studies focused on migraine in association with depression.

For meta-analysis, we used odds ratio (OR) and random effects models. In the search for sources of heterogeneity, we subdivided the studies on the basis of method of migraine and depression diagnosis, sampling, type of contact with subjects, and locality.

The effect of proportional representation of females and sample size on OR variability was tested with meta-regression. Publication bias was verified by a funnel plot and by the Egger's regression test