Molecular-genetic analysis of Alzheimer's dementia in Czech population II: A study of genetic variability of the locus D14S43 examined in a brain tissue of patients with familial Alzheimer's dementia
1997
Abstract
We tested DNA isolated from brain tissue and peripheral blood leucocytes of subjects with FAD. Comparative study included 12 subjects with FAD (DNA isolated from 4 brain areas: frontal, parietal and temporal lobes, and from hippocampus).
These subjects had onset of the disease between ages 40 and 60. A second group included 11 individuals with first signs of AD after the age of 60.
Genetic variability of the locus D14S43 was compared with a control sample (23 subjects older than 90 years) with no history of AD.