Publication at First Faculty of Medicine, Second Faculty of Medicine, Third Faculty of Medicine |
2011
Abstract
Intestinal dysmicrobia (which could manifest itself as diarrhea) represents a frequent undesirable effect of antibiotic therapy. In the management of complications associated with antibiotic treatment application of probiotics is recommended.
Resistance to antibiotics represents a significant precondition of effectiveness of a probiotic. Ofcourse, mere documentation of resistance to antibiotics is not sufficient in terms of safety profile of a probiotic strain.
It should also prove that the resistance is not tranferable to other microorganisms. Spore-forming Bacillus clausii show high resistance to antibiotics that is not tranferable to other microorganisms, thus meeting the standard demands on efficiency, but also on safety of therapy.