DNA adducts are formed from ellipticine and ellipticine-human serum albumin (Elli-HSA) in cells transfected with cytochrome P450
2000
Abstract
Ellipticine is an antitumor drug interacting with DNA by intercalation. We demonstrate a covalent binding of this drug after its activation by CYPs in vitro,and in cells transfected with these enzymes