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Metabolism of N-nitrosoamines (NMA, NDMA) by rabbit liver microsomal system

Publication at First Faculty of Medicine, Faculty of Mathematics and Physics |
2001

Abstract

Carcinogenic nitrosamines (NMA and NDMA) are effectively metabolized by both microsomal cytochrome P450 samples induced by phenobarbital, ethanol and rifampicin, and purified reconstituted enzymes CYP 1A, 2B, 2E and 3A.