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ANTICANCER DRUG ELLIPTICINE ACTS AS AN INDUCER OF CYTOCHROMES P450 1A1/2 AND POTENTIATES ITS OWN PHARMACOLOGICAL EFFICIENCY

Publication at First Faculty of Medicine, Faculty of Mathematics and Physics |
2003

Abstract

The expression of hepatic CYP1A1/2 enzymes in rats of both sexes is strongly induced by anticancer drug ellipticine. The induction is transient and strongly dependent on the dose.