Abstrakt
Vinyl chloride as a compound with carcinogenic and mutagenic effects constitutes a high hazard to persons exposed to it in its production and polymerization processing to the well known plastics - poly(vinyl chloride). Considering this hazard the efficient metabolites are chlorooxirane and chloroacetaldehyde, or its oxidation product - monochloroacetic acid.
To check the individual exposure to vinyl chloride, the use of passive dosimeters or following the concentration of the main metabolite - thio-diglycolic acid - in urine are most suitable. Modern methods of determining cyclic adducts induced in DNA by the efficient metabolites will contribute to the knowledge of interactions of chemical substances with biological systems.