Improvement of the growth prognosis in boy with central precocious puberty and growth hormone deficiency after parallel treatment with growth hormone and gonadoliberine analog D-Trp-6-LHRH
Abstract
A boy with organically conditioned central precocious puberty and growth hormone deficiency (congenital cyst in the area of the third ventricle) is treated concurrently with an analog of gonadoliberine D-Trp-6-LHRH (triptorelin) and growth hormone. Treatment was started at the calendar age of 9.4 years and bone age of 10.8 years.
At the end of the first year of treatment the progression of bone age within one calendar year declined from 1.9 to 1.4 and after 18 months of treatment to 1.3. The growth rate increased from the initial value of 7.9 cm/year to 12.1 cm/year after 12 months of treatment, and subsequently reached a stable level of 10.2 cm/year.
The growth prognosis increased markedly from the initial value of 168 cm to 174 cm at the end of the first year; a further improvement to 176 cm was recorded after 18 months of treatment.