Molecular-genetic analysis of Alzheimer's dementia in Czech population II: The variabilty of apolipoprotein E /Apo E/ gene
1997
Abstract
This study demonstrates the significance of the apolipoprotein E gene and specifically the allele e4, for the expression of Alzheimer's disease/AD/ in the Czech population. A comparison of the prevalence of the ApoE e4 in subjects with Alzheimer's dementia and in normal controls shows an increased allele frequency in the AD group (0,41 in males and 0,47 in females vs 0,16 in a group of normal subjects with no history of Alzheimer's disease).
The genotypes have been determined using the polymerase chain reaction and restriction analysis. It is thus very likely that the presence of the ApoE allele e4 in homozygous and heterozygous form represents a risk factor for Alzheimer's disease.