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Adjuvant arthritis in the rat is associated with decreased binding of nuclear receptors to thyroid hormone responsive element in spleen extracts

Publikace na 3. lékařská fakulta |
1998

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

In vertebrates, thyroid hormone and its cognate nuclear receptors are involved in a complex arrangement of physiological and developmental function. Since thyroid hormone has also been shown to affect immune responses, we investigated the DNA binding status of T-3 receptors of spleen nuclear extracts in a) rats with adjuvant arthritis (AA); b) adrenalectomized rats (ADX), and c) animals with adjuvant arthritis followed by adrenalectomy (AA+ADX).

A marked diminution in the functional binding of nuclear thyroid hormone receptors to DR4 thyroid hormone responsive DNA element was found in the spleens of AA and AA+ADX rats when compared to a control group or ADX rats. The data based on in vivo experiments suggest that the nuclear receptor - thyroid hormone responsive element complex status within the eel nucleus may be altered in adjuvant arthritis.