Publication at Faculty of Pharmacy in Hradec Králové |
1998
Abstract
1. The transplacental transfer Of D-Xylose was investigated in the present study.
2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound.
3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subsequent accumulation in the foetal compartment (the F-M ratio being
2.23 at the end of the experiments). In contrast, no transfer in the F-M direction was observed.
4. A possible facilitation of the transplacental transfer of D-Xylose from the mother to foetus in rats is suggested.