HPLC assay in plasma and preliminary pharmacokinetic study of a quinazolinone derivative with spasmolytic effect

Abstract

An analytical method for analysis of 3-(o-bromo)-phenyl-2-(2,3-dihydroxypropylthio)-4(3H)-quinazolinone from rat plasma using HPLC with reversed phase C18 and liquid-liquid extraction was developed. This method was used for a pharmacokinetic study in rat