Abstract
The work deals with the combination of chitosan and isoniazid, which is the antituberculotics of the first row, the formation of its prodrug forms, which would be well soluble in water and less hepatotoxic than isoniazid alone; for connection of hydroxyl or amino group of chitosan with isoniazid was chosen carboxymethyl or N-succinanhydride bridge wit activation by N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide