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Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: Cellular iron chelation mediating cytotoxic activity

Publication at Central Library of Charles University, Faculty of Pharmacy in Hradec Králové |
2008

Abstract

Thiosemicarbazones and N,N-dimethylthiosemicarbazones derived from acetylpyrazines were prepared; the compounds were tested for antifungal effects on eight strains of fungi and also for antitumor activity against SK-N-MC neuroepithelioma cells; the mechanism of action of the compounds was due, at least in part, to its ability to act as a tridentate ligand that binds metal ions