Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes - Chiral discrimination

Abstrakt

Glucuronidation of flobufen and its major metabolite M17203 has been implicated as an important mechanism of flobufen elimination; o-glucuronides were identified in rat liver microsomes and different enzyme kinetics for two enantiomers was found