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New hydrophobicity constants of substituents in pyrazine rings derived from RP-HPLC study

Publication at Central Library of Charles University, Faculty of Pharmacy in Hradec Králové |
2008

Abstract

New hydrophobicity constants of substituents on pyrazine based on RP-HPLC results were derived; the constants are markedly different from tabulated constants for benzene rings, and can be widely used in estimating physicochemical properties of new biologically active pyrazines