Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases

Abstrakt

The purpose of this study was to test the applicability of n-in-one (coctail) incubations in the determination of intrinsic clearance (CIint) as the slope of the linear portion of the Michaelis-Menten curve (velocity V vs. substrate concentration [S] where substrate concentrations were low