Synthesis of (2E)-2-methyl-3-(4-{[4-(quinolin-2-yl-methoxy)phenyl]sulfanyl}phenyl)prop-2-enoic acid (VUFB 20609) and 2-methyl-3-(4-{[4-(quinolin-2-yl-methoxy)phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as potential antileukotrienic agents

Abstract

Synthesis of chiral and nonchiral homologues, azanalogues and isosters of the quinlukast, an potential dual antileukotrienic drug; their antiinflammatory, antiplatelet, antimycotic and antitubercular evaluation