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Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: Effects of linking chain length, chirality and polyfluorination

Publication at Faculty of Pharmacy in Hradec Králové |
2009

Abstract

Series of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking chain length and polyfluorination were investigated.

Novel highly active enhancers with advantageous properties were identified.