Cytostatic tetrazole-butenolide conjugates: linking tetrazole and butenolide rings via Stille coupling and biological activity of the target substances

Abstrakt

A series of tetrazoles linked to the butenolide core via benzene rings were prepared by the Stille coupling reaction of alpha-(tributylstannyl)butenolides and 5-(alkylsulfanyl)-1-(4-iodophenyl)tetrazoles, and the compounds were tested for antifungal and cytostatic activity.