Abstract
MEN 1 syndrome involves various combinations of more than 20 types of endocrine tumors and neendokrinních. For MEN 1 is patognomická primary hyperparathyroidism (parathyroid adenoma in 90 - 95% of patients with MEN 1), which usually manifests itself as the first symptom of MEN 1, between puberty ua 30th years of age, the symptoms may often be dull.